Head of Clinical Excellence & Innovation

Head of Clinical Excellence & Innovation - Inflammation & Immunology (I&I)

The Head of Clinical Excellence & Innovation - I&I will be a pivotal leader driving the company's clinical innovation and excellence across Pfizer's global I&I portfolio. Reporting to the Chief Development Officer for I&I, Christian Antoni, this leader will set and execute a compelling vision for clinical program performance, leveraging technology, data, and industry-leading strategies to accelerate the development of transformative therapies in I&I.

This position will be based out of Cambridge, Massachusetts.

Position Summary

• Strategic Oversight & Vision: Shape and drive the strategic direction for I&I clinical programs, championing the adoption of innovative trial designs while upholding the highest standards of scientific rigor and regulatory excellence.

• Team Leadership & Culture: Inspire, mentor, and develop our clinical leaders and scientists in I&I drug development, fostering an environment of innovation, accountability, and continuous learning, while championing Pfizer's commitment to patient‑centricity, entrepreneurial thinking, and data‑driven excellence. This role will have direct responsibility for all physicians and clinical scientists who do not report directly to the other head's of development in I&I.

• Technology & Data Leadership: Spearhead the integration of AI, digital health solutions, and advanced analytics to transform trial operations, enhance data integrity, and empower data‑driven decision‑making throughout the clinical development journey.

• Process Optimization: Proactively identify, implement, and scale best‑in‑class practices to streamline processes, boost operational efficiency, and build a flexible clinical infrastructure that supports Pfizer's growth ambitions and accelerates impact.

• External Engagement: Act as a visible ambassador for Pfizer at scientific conferences, regulatory forums, and partner or investor engagements - articulating the company's vision and cultivating strong relationships with KOLs, CROs, academic collaborators, and regulatory stakeholders.

• Cross‑Functional Partnership: Work closely with Medical Affairs, Regulatory, Safety, Operations, and Business Development teams to harmonize and advance I&I clinical strategies and standards across the organization.

• Industry Foresight: Continuously scan and interpret the evolving scientific and competitive landscape, leveraging emerging technologies and disruptive trends to inform and evolve Pfizer's clinical strategy in I&I.

The Global Head, Clinical Excellence & Innovation will drive the vision for clinical program excellence and transformative innovation within Pfizer's I&I division. This leader will be responsible for shaping and executing robust clinical trial performance, protocol development, and strategic leadership in a highly dynamic, patient‑focused, and data‑driven environment. He/she will be responsible for leading the pool of physicians and clinical scientists who perform the studies and are the pool we will recruit from our future leaders (Global Clinical Leads and Global Project Leads).

The successful candidate will be a hands‑on thought‑leader with expertise in clinical development, process optimization, and cross‑functional collaboration‑combined with a passion for leveraging new technologies and approaches to expand impact for patients and partners.

• Provide strategic oversight for the design, execution, and ongoing excellence of clinical programs, championing innovation across all phases of drug development.

• Lead the group of physicians and clinical scientists including mentorship, career building and effective staffing of the projects.

• Lead the Protocol Review Committee in the development, review, and optimization of clinical trial protocols, ensuring scientific rigor and regulatory compliance.

• Identify, evaluate, and implement best practices for process improvement and operational efficiency throughout the clinical development lifecycle.

• Drive the adoption of innovative trial designs to enhance clinical impact and accelerate value creation.

• Ch…