Chief of Staff to COO

Cambridge, Massachusetts, United States

Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes. The Iterative Health Site Network is a premier network of 70+ clinical research sites across US and Europe accelerating the path to market for gastrointestinal (GI) and hepatology novel therapies. Our focus is on driving the success and growth of our partner sites by empowering them with tech-enabled services.

By combining deep expertise in clinical trials with cutting-edge AI, we empower research teams and study sponsors to expand and expedite access to novel therapeutics for patients in need.

About the Role

We are seeking a high-impact Chief of Staff to the COO to serve as a strategic partner, integrator, and force multiplier for our Chief Operating Officer. The COO oversees our entire clinical trial operations business – spanning US and ex-US site operations, medical, product, technology, business operations, and program management.

This is a rare opportunity to step into a high-visibility leadership role at the center of the organization. The Chief of Staff will support the COO across strategic initiatives, operational execution, cross-functional alignment, and organizational effectiveness. You will help drive the company’s most important priorities, anticipate issues, solve complex problems, and support a rapidly scaling business.

This role is ideal for someone hungry to accelerate their trajectory into senior leadership within clinical research, healthcare operations, or general management.

Responsibilities

• Serve as a trusted advisor and thought partner to the COO, providing clarity, structure, and proactive insights on key decisions.
• Drive operational excellence across the clinical trial operations business by identifying gaps, improving processes, and monitoring progress on strategic initiatives.
• Lead or co-lead special projects critical to scaling the company, including site expansions, performance optimization, trial delivery improvements, and workflow redesigns.
• Prepare analysis, recommendations, briefing documents, and presentations to support COO and executive team decision-making.

• Support and continuously improve the COO’s operating cadence (leadership meetings, etc).
• Own preparation for executive meetings, board discussions, and external partner engagements.
• Draft communication on behalf of the COO, ensuring synthesis and clarity for both internal and external audiences.

• Act as an extension of the COO – representing her in meetings, synthesizing input, and enabling faster decision-making.
• Champion company culture and values; model cross-team collaboration and operational excellence.
• Build strong relationships across all levels of the organization to create cohesion and unblock execution.
• Identify leadership development opportunities for the team; help design and implement organizational improvements.

What We’re Looking For

Required Qualifications

• 4–6 years of experience in management consulting, operations, strategy, program management, healthcare/clinical research operations, or a comparable high-performance environment.
• Proven ability to lead complex cross-functional projects with structure, clarity, and measurable outcomes.
• Exceptional problem-solving skills; able to break down ambiguity into actionable steps.
• Excellent executive communication – clear, concise, and adaptable to technical and non-technical stakeholders.
• Ability to build trust quickly, manage up, and influence without authority.
• Highly organized, detail-oriented, and comfortable managing multiple priorities in a fast-growth environment.
• Relentlessly resourceful – willing to get deep into operational details while also thinking strategically.

Preferred Qualifications

• Experience in health-tech, clinical research, or AI-driven healthcare solutions.
• Exposure to C-suite advising, board engagement, or executive-level decision support.
• Prior experience working inside a scaling startup or operator role.

New York pay range

$190,000 – $250,000 USD

At Iterative Health,…