Executive Medical Director, Hepatology at GSK Cambridge, MA

Overview

GSK is seeking a highly skilled and experienced Executive Medical Director to lead an exciting and expanding Hepatology program, advancing an asset through late-stage development while exploring opportunities for life-cycle management to maximize its therapeutic and commercial impact. This position reports to the VP Clinical Development, CRH, GI & Renal in the Respiratory, Immunology & Inflammation Research Unit (RIIRU) Advanced Pipeline Unit (APU).

About RIIRU: The Respiratory, Immunology and Inflammation Research Unit (RIIRU) was formed in 2024 to identify and advance novel molecular targets with genetic associations to disease based on the foundational observation that targets with human genetic evidence supporting their causal role in the intended indication improves clinical success by two-fold. The remit of RIIRU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform trials through to submission for approvals .

This goal is enabled through strategic external (e.g., Flagship Pioneering, Vesalius, Muna Therapeutics and others) and GSK-internal partnerships (Research Technologies).

Note: This career opportunity requires an on-site office presence (minimum of two days a week) in one of GSK’s US (PA or MA) or UK (London - New Oxford Street or Stevenage) sites.

• Strategic Leadership: Provide medical and scientific leadership for a hepatology asset, driving strategy to achieve clinical, regulatory, and commercial milestones while ensuring alignment with GSK’s strategic priorities.
• Late-Stage Drug Development: Oversee the design, initiation, execution, and closure of late-stage clinical trials, including Phase 3 studies, ensuring delivery of high-quality data to support regulatory approval and commercialization.
• Global Regulatory Interactions: Lead critical regulatory activities, including dossier submissions, preparation for meetings with health authorities (e.g., FDA, EMA, PMDA), and responses to regulatory queries.
• Life-Cycle Management: Identify, develop, and execute strategies to expand the asset beyond its primary indication, exploring significant life-cycle opportunities to maximize its therapeutic and commercial potential.
• Cross-Functional Collaboration: Leverage significant experience working across a complex cross-functional matrix to partner with clinical, translational, commercial, regulatory, and scientific teams.
• Innovation and Competitive Intelligence: Monitor emerging trends, competitor activities, and advancements in hepatology and related fields to identify opportunities for differentiation and strategic growth.
• Team Leadership: Lead and mentor a high-performing team, fostering professional development, providing clear direction, and ensuring alignment with GSK’s values and objectives.
• External Representation: Act as a key representative of GSK's RIIRU in hepatology, engaging with external stakeholders, scientific forums, and professional organizations to advance the company’s visibility and influence in this therapeutic area.

• Medical degree and clinical medical specialty training board qualification/registration.
• Experience in the global pharmaceutical/biotechnology industry in the field of hepatology.
• Experience in clinical research and drug development, with a focus on hepatology.
• Line-management experience overseeing medical directors and/or clinical scientists as well as leading matrix teams within a clinical development setting.
• Experience in late-stage hepatology drug development, including Phase 2 and Phase 3 clinical trial design, initiation, execution, and closure.

• Medical degree and clinical medical specialty training board qualification/registration in Gastroenterology or Hepatology.
• Demonstrated success in life-cycle management, including identifying opportunities for indication expansion and strategic development beyond primary indications.
• Experience with regulatory interactions, including submissions, strategy meetings, and negotiations with health authorities.
• Understanding of the clinical and scientific landscape in hepatology, experience in advancing…