Director, Clinical Pharmacology and Pharmacometrics

Director, Clinical Pharmacology and Pharmacometrics

The Director, a member of the Clinical Pharmacology group at Bristol Myers Squibb, is responsible for ensuring clinical pharmacology support for a portfolio of radiopharmaceutical programs in oncology.

This role includes the creation and implementation of optimized clinical pharmacology plans to advance early development programs through IND/clinical POC, and late‑stage programs through NDA, BLA, MAA, and post‑approval activities. The Director will play an active role in drug discovery and development efforts to advance Rayze Bio’s radiopharmaceutical pipeline.

Flexible across BMS geographic locations including NJ, Cambridge (MA), San Diego (CA), Brisbane (CA), Seattle (WA), and others.

• Serves as a key member of the CP&P leadership team
• Responsible for assigned clinical pharmacology strategy within projects
• Contributes to integrated strategy with Research, Drug Development, and Commercialization
• Develops and executes clinical PK, PK/PD, pharmacometric analyses, and modeling & simulation plans
• Drives decision‑making and strategy over the entire portfolio through effective partnership with partner functions and senior leaders
• Oversees scientific output, conduct and resourcing of clinical pharmacology, PK/PD, working with pharmacometrics and QSP partners
• Supports dose selection, justification, and regulatory filings
• Reviews and approves relevant scientific data and reports for regulatory filings
• Develops technical/leadership skills of clinical and M&S scientists
• Participates in or assigns qualified delegates to support in‑licensing and out‑licensing business development activities
• Represents Clinical Pharmacology on relevant governance committees and works streams
• Oversees planning and execution of clinical pharmacology trials with clinical operations
• Provides input to Phase 2/3 clinical study design and regulatory strategy
• Supervises the development of the Clinical Pharmacology Plan(s)
• Manages design of clinical pharmacology studies, data analysis, interpretation, and reporting
• Serves as a subject‑matter expert in interactions with health authorities
• Builds a collaborative, supportive learning environment

• Ph.D. in pharmacokinetics/pharmaceutical science or relevant field; OR
• Pharm
  
  D with post‑doctoral training;
  Ph.D. and Pharm
  
  D should have at least 8‑10+ years experience in clinical pharmacology; OR
• MS in pharmacokinetics/pharmacology or relevant field with 12‑15 years experience in clinical pharmacology
• Extensive expertise in application of clinical pharmacology in early and late stage drug development
• Experience leading/managing a clinical pharmacology team/group
• Experienced in advanced quantitative analysis and model‑informed drug development approaches
• Track record of regulatory interactions and deliverables (IND, NDA, BLA, MAA filings)
• In‑depth knowledge of current practices and issues in Clinical Pharmacology and Pharmacometrics
• Strong written and oral communication skills for scientific presentations
• Ability to work in a dynamic team‑oriented environment
• Experience managing a team of CP&P scientists and providing mentorship
• Independent lead for one or more assets in BMS drug development program
• Demonstrated leadership, expanded influence, and stakeholder management in a matrix environment
• Programming experience in NONMEM, R, Win Nonlin, SAS, Splus
• Quantitative data analysis, POP PK/PD, and data visualization skills highly desired
• Experience in radiopharmaceuticals is a plus

Brooklyn – CA – 226,130–274,021
Cambridge – 226,130–274,021
Princeton – NJ – 201,910–244,666
San Diego – Rayze Bio – CA – 218,060–264,236
Seattle – 1000 Dexter – WA – 218,060–264,236

Medical, pharmacy, dental, and vision care; wellbeing support; financial wellness resources; 401(K); life insurance; disability; family leave; and more. For complete details, visit

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