Clinical Lab Process Development Associate - Cell Factory

Overview

The Genomics Platform is dedicated to solving the world’s most challenging biomedical problems through the continuous development and investment in cutting edge technology and large-scale research projects that are both challenging and complex. In support of continually changing initiatives, the Clinical Laboratory Process Development Associate I is committed to carrying out innovative, high-throughput lab processes and supporting the highest quality research to understand the impacts of genetic regulation on human health and disease.

In this role, you are responsible for processing samples through a high throughput clinical research laboratory and meeting production goals.

In this position, you will complete multi-step processes for cell expansion, banking, perturbations, screens and working to develop cellular models of disease and biological processes of interest to researchers. In addition to standard production processes, this position will require individuals to participate in continuous improvement solutions through appropriate change management procedures and troubleshooting processes as needed.

The individual may be involved with the designing and executing of development, process improvement, or troubleshooting projects under direct guidance from the supervisor in support of platform goals and may be required to complete related training in JMP, Six Sigma, or other process improvement methods. Upon completion of these projects the individual is responsible for documenting and communicating results to others in the Platform during dedicated meetings.

In addition, PDAs will assist with the general supervision of work of other laboratory personnel such as Process Development Technicians and Accessioning Technicians as required.

• Maintain and optimize mammalian cell culture systems for screening experiments.
• Apply functional genomics techniques, including epigenomics, single-cell, transcriptomics, and CRISPR-based assays in human cells and tissues.
• Follow standard operating procedures.
• Each individual performs only those high complexity tests that are authorized by the Laboratory Director and require a degree of skill commensurate with the individual’s education, training, experience, and technical abilities.
• Tests will require the exercise of independent judgment and responsibility with minimal supervision by the laboratory director or supervisor.
• Adhere to the laboratory’s quality control policies, document all quality control activities, instrument and procedural calibrations and maintenance performed.
• Follow the laboratory's established policies and procedures whenever test systems are not within the laboratory’s established acceptable levels of performance.
• Be capable of identifying problems that may adversely affect test performance or reporting of test results. Correct the problems according to procedures or immediately notify the General Supervisor, Technical Supervisor, Clinical Consultant or Laboratory Director.
• Document all corrective actions taken when test systems deviate from the laboratory's established performance specifications.
• Review and monitor quality metrics and communicate results to others in the Platform during dedicated meetings as needed.
• BS/BA degree in Biology or Chemistry.
• 1+ years of relevant full time laboratory experience in this specialty subsequent to obtaining B.S./B.A. degree is required.
• Working, solid knowledge of basic aseptic / mammalian cell culture laboratory techniques required as a part of the above 1 year of experience.
• Strong analytical skills, problem solving ability, and innovation aptitude required.
• Recent (within the last year) laboratory experience with the use of standard cell lab equipment such as pipettes, centrifuges, biosafety cabinets, microscopes, gel electrophoresis required.
• Knowledge of high-throughput screening and automation and/or experience working in a high throughput production setting is desired, but not required.
• Experience with genome editing tools including CRISPR targeting in various human cell types is preferred.
• Strong hands-on experience in molecular biology, genomics, and cellular biology…