Analytical Chemist - Biophysical Characterization

Overview

Boston, MA, USA

Full-time

Company Description

The work we do at Eurofins Professional Scientific Services matters, and so do our employees. At Eurofins PSS, we put a focus on your professional growth. We provide our employees the ability to break into the biopharmaceutical industry and grow from the bottom up. We have the supportive teams and tools available to invest in you while also affording you work-life balance and a competitive benefits package.

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate.

Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.

If you’re looking for a rewarding career, a place to call home, apply with us today!

Job Description

Eurofins is seeking a highly skilled, passionate, and motivated scientist to join our client Analytical Development team to support testing non-GMP samples for development studies such as comparability assessments, process development, stability, product, and process characterization. The Analytical Development team is responsible for developing and implementing new analytical methods, as well as optimizing and improving current methods for the characterization of raw materials, RNA drug substances, and LNP products and programs at various development stages.

• Develop, optimize, and execute analytical methods intended for a variety of purposes, including release and stability testing, product characterization, high-throughput analysis, and perform assays for characterization of complex raw materials.
• Review, interpret, and present data within the analytical team and cross-functionally.
• Provide technical oversight for troubleshooting and phase-appropriate qualification and validation of analytical assays for the analysis of gRNA, mRNA, and LNP.
• Work in partnership with internal and/or external QC to coordinate analytical method transfer within the organization or at Contract Manufacturing Organizations (CMOs)/Contract Testing Laboratories (CTLs).
• Author, review, and revise technical source documents to support phase-appropriate comparability.
• Serve as the CMC representative on cross-functional project teams.
• Provide technical oversight to guide analytical/QC investigations, as needed.
• Actively collaborate with internal and external process development and quality teams.
• Train and mentor junior team members

Qualifications

Basic

Minimum Qualifications:

• Ph.D. in Analytical Chemistry, Biochemistry, Biophysics, or related field with 2-4 years of biotech industry experience or M.S. degree with 3-7 years of biotech industry experience or B.S. degree with 5+ years of biotech industry experience.
• Hands-on experience developing, qualifying and troubleshooting biophysical assays using analytical techniques such as HPLC/UPLC, MS, UV/Vis, and FTIR.
• Hands-on experience developing analytical methodologies such as IP-RP, IEX, LC-fluor, multi-modal LC, etc.
• Strong technical background on advanced characterization instrumentation such as MALS, and LC-MS NTA.
• Proficiency with Waters and Agilent LCs.
• Proficiency with software systems such as Open Lab, Empower, and ELN (Benchling is a plus).
• Previous experience developing methods for mRNA (gRNA and LNP are a plus).
• Excellent scientific knowledge in analytical chemistry with a conceptual understanding of solid-phase oligonucleotide synthesis and purification strategies.
• Familiarity with applicable ICH regulations and multi-compendial guidelines related to method validation.
• Experience in assay development, qualification, validation, and implementation to support target candidate validation from non-GxP to GMP environments.
• Proven track record of success collaborating effectively with cross-functional teams.
• Ability to balance multiple responsibilities, prioritize activities, and navigate ambiguity.
• Demonstrated learning agility, scientific problem solving, and strong written and verbal communication skills.
• Proactive, creative, and positive attitude.
• Unwavering commitment to safety protocols and procedures.

Preferred Qualifications:

• Strong understanding of advanced characterization technologies and data interpretations such as cryo-TEM, NMR, DLS, AUC, etc.
• Advanced understanding of lipid nanoparticle delivery, production, and purification.
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Additional…