Scientist, Peptide Chemistry

MBX Biosciences is looking for a talented and motivated Peptide Chemist to join our dynamic research and development team. The successful candidate will be instrumental in designing, synthesizing, and characterizing novel peptides to support our drug discovery programs. Reporting to our Director of Chemistry, this position provides an excellent opportunity to work at the forefront of peptide therapeutics within a collaborative and innovative environment.

• Synthesize peptides and peptide analogs using advanced techniques, such as solid-phase peptide synthesis and solution-phase synthesis. Experience with Solid-phase peptide synthesis is highly desirable.
• Perform the purification and characterization of peptides using HPLC, mass spectrometry, and other analytical techniques.
• Contribute to the design and modification of peptides to enhance pharmacological properties, including stability, bioavailability, and target specificity.
• Collaborate with cross-functional teams, including biology, pharmacology, and formulation scientists, to advance peptide candidates.
• Maintain accurate and detailed experimental records, and prepare technical reports and presentations.
• Maintain and support highly organized laboratory including consumables and reagent ordering and tracking.
• Stay up to date with the latest advancements in peptide chemistry and related fields through literature reviews and participation in scientific conferences.

• PhD or MS in Analytical Chemistry, Biochemistry, Chemistry, or a related field; or, BS in Analytical Chemistry, Biochemistry, Chemistry, or a related field with a minimum of 2 years of relevant experience.
• Demonstration of strong scientific and leadership skills that drive results.
• Must demonstrate excellent teamwork, attention to detail, and problem-solving abilities.
• Highly self‑motivated, driven, can‑do, make‑it‑happen attitude with the ability to own and drive projects.
• Strong collaborator with cross‑functional teams and external partners.
• Capable of continuous learning, open‑minded, curious, highly organized, and detail‑oriented.

You will be expected to travel periodically based on the needs of the business to the extent requested by the Company including attendance at Together Weeks, Together Days and functional meetings as requested by the Company.

MBX Biosciences, Inc. (NASDAQ: MBX) is a clinical‑stage biopharmaceutical company focused on the discovery and development of novel precision peptide therapies for the treatment of endocrine and metabolic disorders. The Company was founded by global leaders with a transformative approach to peptide drug design and development. Leveraging this expertise, the Company designed its proprietary Precision Endocrine Peptide™ (PEP™) platform to overcome the key limitations of unmodified and modified peptide therapies and to improve clinical outcomes and simplify disease management for patients.

PEPs are selectively engineered to have optimized pharmaceutical properties, including extended time‑action profiles and consistent drug concentrations with low peak‑to‑trough concentration ratios, consistent exposure to target tissues, and less frequent dosing. The Company is advancing a pipeline of novel candidates for endocrine and metabolic disorders with clinically validated targets, established endpoints for regulatory approval, significant unmet medical needs and large potential market opportunities.

The Company’s pipeline includes its lead product candidate MBX 2109, in Phase 2 development for the treatment of chronic hypoparathyroidism (HP); MBX 1416, in Phase 1 development for the treatment of post‑bariatric hypoglycaemia (PBH); and an obesity portfolio that includes MBX 4291, as well as multiple discovery and pre‑clinical candidates in development for the treatment of obesity. The Company is based in Carmel, Indiana.

To learn more, please visit the Company website at  and follow us on Linked In.

MBX Biosciences is an Equal Opportunity Employer and is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.