Principal Scientist; ADME

About Atrium

What you do matters. As a people‑centric organization, we foster an environment of collaboration, high performance, and innovation where your talents are valued and your achievements are celebrated. Join us and become part of an inclusive team.

Our client is a well‑established biotech company focused on modernizing ADME by leveraging expertise in high‑throughput screening to enhance the in vitro small‑molecule drug discovery pipeline. They are currently seeking a Principal Scientist (ADME) to join their growing team.

$70/hr – $80/hr

The Principal Scientist (ADME) will develop and execute advanced in‑vitro ADME assays and support accelerated drug discovery by delivering high‑quality ADME data for lead optimization. This individual will play a key role in assay development, automation, and data interpretation within a high‑throughput environment.

• Develop, optimize, and validate high‑throughput in‑vitro ADME assays covering solubility, permeability, protein binding, metabolic stability, and enzyme inhibition/induction.
• Utilize automated liquid handling systems for assay automation and screening.
• Perform and troubleshoot mass spectrometry analyses, including method development.
• Manage sample preparation and conduct data analysis to calculate pharmacokinetic parameters.
• Communicate results and provide recommendations to cross‑functional project teams.
• Maintain laboratory documentation and ensure compliance with quality and safety standards.

• Ph.D. (2+ years industry experience) or Master’s degree (5+ years industry experience) in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or related field.
• Hands‑on experience with LC‑MS or acoustic mass spectrometry in high‑throughput settings.
• Proven ability in automated in‑vitro ADME assay development.
• Strong knowledge of drug metabolism pathways and DMPK.
• Familiarity with ADME prediction and data visualization tools.

• Experience with laboratory automation and electronic data capture systems.
• Programming skills (e.g., Python, R) and data visualization expertise.
• Experience with clinical sample handling and CRO environments.

A Ph.D. or Master’s degree in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or related field is required.

• Medical, dental, and vision insurance.
• 401(k) plan.
• Holiday pay and sick time.
• Additional comprehensive benefits offerings.

As a woman‑owned firm, we value diversity. We are an equal‑opportunity and affirmative action employer and will consider all applications without regard to race, sex (including gender, pregnancy, sexual orientation and gender identity), age, color, religion or creed, national origin or ancestry, veteran status, disability (physical or mental), genetic information, citizenship or any other characteristic protected by law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Candidates who apply for roles through the Atrium website will be added to our candidate pool and may be considered for additional roles of a similar title. Please contact us to request an accommodation.

EOE/M/F/D/V/SO