Sr Lab Technician, Mass Spectrometry Facility

Sr Lab Technician, Mass Spectrometry Facility

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The Sr Lab Technician of the shared Research Mass Spectrometry Facility within the Department of Chemistry and Chemical Biology will be responsible for operating a key research facility for Northeastern University and its partners. Specifically, the Sr Lab Technician will be charged with operating and maintaining chromatography and mass spectrometry equipment, performing sample preparation, conducting data analysis, partnering with researchers on method development and evaluation, and training students and others on the use of the Facility and its equipment.

This person will work closely with the Associate Director of the Facility and will periodically interact with the Faculty Director of the Facility.

The Sr Lab Technician will also lead other administrative duties related to operating the laboratory efficiently. This will include overseeing a shared consumables budget and associated ordering, setting up service contracts for equipment, ensuring all equipment is properly maintained, and working as a liaison to college and university space and safety staff.

Services provided on a regular basis by the Facility include protein identification, quantitative proteomics, quantitative metabolomics, targeted small-molecule quantification, and protein characterization (intact mass analysis). The position requires interaction with many researchers, strong communication and organizational skills, and the ability to train users and manage multiple projects at once.

• Operate and maintain chromatography and mass spectrometry equipment; prepare samples.
• Troubleshoot, maintain, and operate liquid chromatographs, mass spectrometers, and other equipment used in analysis of biological and chemical samples, including biological fluids, tissues, cells, and bacteria.
• Train students and prospective users who will operate mass spectrometers frequently.
• Assist the Associate Director in developing new methods, particularly in single‑cell proteomics and small‑molecule quantification, and contribute to equipment and training proposals.
• Work with the Associate Director and the College Safety Officer to maintain a safe working environment and address identified laboratory safety and facilities issues immediately.
• Help manage a consumables budget, monitor spending, and initiate purchases on behalf of the laboratory; assist in managing instrument service contracts.

• M.S. in Chemistry, Biochemistry, Analytical Chemistry, or related field, or Bachelor’s degree with 1‑5 years of relevant post‑graduate experience required.
• Hands‑on proficiency with LC‑MS/MS for protein and peptide identification and characterization, and small molecule analysis.
• Experience with protein sample preparation, small molecule extraction, and data processing (using open‑source software such as Max Quant, Perseus, and Skyline) required.
• Solid understanding of proteomics, metabolomics, protein chemistry, and protein characterization methods preferred.
• Experience with protein identification and characterization of post‑translational modifications, and in‑depth knowledge of Orbitraps, triple quadrupole, and TimsTOF instrument operation and maintenance, data interpretation, and background literature preferred.
• Interest or expertise in single‑cell and limited‑sample proteomics highly desirable.
• Knowledge of R or Python coding desirable but not necessary.

• Resume/CV
• Cover letter

The University is unable to sponsor for this role, now or in the future.

Research

Full‑time

Research, Analyst, and Information Technology

Higher Education

106H

$23.02 - $31.66

All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, religion, color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law.

Additional benefits: medical, vision, dental, paid time off, tuition assistance, & life, retirement, as well as commuting & transportation.

With the pay range(s) shown above, the starting salary will depend on several factors, which may include your education, experience, location, knowledge and expertise, and skills as well as a pay comparison to similarly‑situated employees already in the role. Salary ranges are reviewed regularly and are subject to change.