Senior Director, US HCP Marketing

Posted Monday, November 10, 2025 at 8:00 AM

Xenon Pharmaceuticals ( NASDAQ:

XENE ) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy and depression. Our flagship azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. Building upon the positive results and compelling data from our Phase 2b “X-TOLE” study in adult patients with focal epilepsy, our Phase 3 epilepsy program includes multiple clinical trials evaluating azetukalner in patients with focal onset seizures and primary generalized tonic-clonic seizures.

In August 2025, we announced the completement of patient recruitment in our Phase 3 X-TOLE2 study and topline data are anticipated in early 2026. We also have multiple Phase 3 azetukalner clinical trials in major depressive disorder (MDD) and bipolar depression (BPD) underway, based on topline data from our Phase 2 “X-NOVA” clinical trial. In addition, we are proud of the leading-edge science coming out of our discovery labs, including early-stage research programs that leverage our extensive ion channel expertise and drug discovery capabilities to identify validated drug targets and develop new product candidates, and have recently initiated Phase 1 studies for our follow‑on Kv7 channel opener, XEN
1120, and our lead Nav
1.7 development candidate, XEN
1701, in pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking an experienced Senior Director, US HCP Marketing
, with a passion for building a brand, growing a function and capabilities and delivering a successful first launch for a late-stage, Phase 3 company. The Senior Director, US HCP Marketing, will be an integral member of Xenon’s Marketing team and play a critical role in preparing and delivering the successful launch of our lead candidate and first product, azetukalner, in the multi-billion-dollar epilepsy category.

More specifically, they will build a high-performing HCP Marketing team and be responsible for shaping brand and US launch strategies and leading a promotional plan that accomplishes azetukalner’s market aspiration and business goals in epilepsy. This is an exciting and rewarding opportunity for an experienced marketer seeking to lead the potential launch of a novel, high-value product and make a significant positive impact for patients.

This position reports to the Vice President, Marketing and will be based in Boston, MA, USA. We will consider other jurisdictions for exceptional candidates.

The level of the position will be commensurate with the candidate’s education and industry experience. Relocation and immigration support will be provided, if required. This role is a hybrid position, requiring a minimum of 2 days per week in the office.

• Shape azetukalner brand and US launch strategy in collaboration with VP, Marketing and cross‑functional partners
• Lead development of brand positioning, and development of HCP‑focused disease state and brand strategic narratives, core messages and campaigns
• Collaborate with Patient Marketing to ensure consistency in positioning and messaging strategy
• Partner with customer‑facing and market access teams to ensure an outstanding customer experience aligned with brand vision and strategy
• Partner with Commercial Business Insights to shape a competitive intelligence, analytics and market research plan to build, refine and measure strategy, including competitive monitoring, HCP targeting and segmentation, positioning research, customer segment profiles and deep dives,…