Vice President, Engineering

About Formation Bio

Formation Bio is a tech and AI‑driven pharma company differentiated by radically more efficient drug development. Advancements in AI and drug discovery are creating more candidate drugs than the industry can progress because of the high cost and time of clinical trials. Recognizing that this development bottleneck may ultimately limit the number of new medicines that can reach patients, Formation Bio, founded in 2016 as Trial Spark Inc.,

has built technology platforms, processes, and capabilities to accelerate all aspects of drug development and clinical trials. Formation Bio partners, acquires, or in‑licenses drugs from pharma companies, research organizations, and biotechs to develop programs past clinical proof of concept and beyond, ultimately helping to bring new medicines to patients. The company is backed by investors across pharma and tech, including a16z, Sequoia, Sanofi, Thrive Capital, Sam Altman, John Doerr, Spark Capital, SV Angel Growth, and others.

• Our Vision for AI in Pharma
• Our Current Drug Portfolio
• Our Technology & Platform

Formation Bio is seeking a bold and forward‑thinking Vice President of Engineering to lead and transform our technical capabilities into a strategic driver of clinical and commercial success. This critical leadership role will report to the CTO and serve as a senior thought partner in defining how sophisticated engineering and computational frameworks can fundamentally reshape drug development and asset acquisition. The ideal candidate is a biotech‑native technical leader who understands that our goal is not to build traditional software products but to develop deep technical capabilities that drive hard insights.

You will partner closely with Product to translate complex scientific and operational bottlenecks into high‑leverage technology solutions that accelerate workflows and deliver higher‑quality insights. You will oversee the engineering behind complex data science analyses—including Real‑World Evidence (RWE) platforms, large‑scale information ingestion pipelines, and comprehensive modeling—to move the needle for pharma decision‑making. You bring the vision and biotech experience to ensure our technical foundation supports clinical‑stage assets and highly regulated R&D workflows with precision and speed.

• Define and execute a technical vision that prioritizes high‑leverage computational capabilities over traditional software features, ensuring engineering effort directly increases drug asset quality and value.
• Act as a core collaborator for the CTO and leadership team, translating complex clinical and business bottlenecks into scalable engineering solutions.
• Embed engineering resources within Business Development, Clinical, and R&D units to leverage technology to address operational needs.
• Partner with Data Science to build the engineering architecture required for complex analysis, including Real‑World Evidence (RWE) platforms, asset screening frameworks, and prediction pipelines.
• Collaborate with Product to build specialized tools that streamline R&D workflows, moving the needle from manual efforts to technology‑augmented insight generation.
• Develop and scale proprietary platforms for the ingestion and operationalization of external, clinical, and biological datasets.
• Ensure the delivery of GxP‑validated clinical environments and automated security compliance, maintaining a regulatory‑first posture without sacrificing speed.
• Deploy and scale LLM‑integrated features and autonomous agents to drive multiplier efficiencies across the organization.
• Manage and mentor a specialized engineering organization, fostering a high‑performance culture that values technical rigor, interdisciplinary collaboration, and mission‑driven delivery.
• Refine the team structure to maintain high talent density and quality engineering in a fast‑paced biotech environment.

• 10+ years of experience in software/data engineering and technical leadership, with a significant background in the Boston biotech or pharma‑tech ecosystem.
• Biotech Intuition:
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