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Principal Engineer, Cloud Infrastructure

Job in Boston, Suffolk County, Massachusetts, 02298, USA
Listing for: Vertex Pharmaceuticals
Full Time position
Listed on 2026-02-03
Job specializations:
  • IT/Tech
    Cloud Computing, Systems Engineer
Job Description & How to Apply Below
*
* Location:

** Boston, MA (Vertex Headquarters) The Principal Cloud Infrastructure Engineer will lead the design, implementation, and optimization of enterprise-scale Azure cloud infrastructure with a strong emphasis on automation, operational excellence, and emerging AI technologies. This role will serve as a technical leader responsible for architecting resilient, scalable, and secure cloud solutions that support critical business operations while driving automation-first approaches and ITIL best practices.

The Principal Engineer will champion the integration of GenAI capabilities to enhance infrastructure operations, reduce manual toil, and accelerate cloud service delivery across the enterprise.
** Key

Duties & Responsibilities
** Lead the design and evolution of enterprise Azure infrastructure, including compute, storage, networking, and platform services. Define technical standards, reference architectures, and cloud-native patterns that align with business objectives, security requirements, and industry best practices. Serve as the primary technical authority for Azure infrastructure decisions.

Partner with Information Security, Compliance, and Privacy teams to ensure cloud infrastructure adheres to regulatory requirements, security frameworks, and data protection standards. Implement Azure Policies, landing zones, and governance controls that enforce compliance while enabling developer agility.

Design and maintain robust disaster recovery and business continuity solutions using Azure Site Recovery, backup services, and multi-region architectures. Conduct regular DR testing and ensure infrastructure resilience meets business requirements.
** Required Education*
* ** Required Experience
** Typically requires 10+ years of experience in infrastructure engineering, cloud architecture, or the equivalent combination of education and experience 5+ years of hands-on experience with Microsoft Azure infrastructure and services Experience implementing automation frameworks and IaC practices at scale
** Required Knowledge/Skills
** Expert-level knowledge of Microsoft Azure services including Virtual Networks, Azure Kubernetes Service (AKS), Azure Virtual Machines, Storage, Azure Active Directory, and Azure Monitor

Experience with AWS cloud infrastructure is strongly preferred

Familiarity with GenAI technologies, including Azure OpenAI Service and AI-assisted operations tools Proficiency in scripting and programming languages (Power Shell, Python, Bash)
Knowledge of networking concepts, including VPN, Express Route, DNS, load balancing, and firewall architectures

Understanding of security frameworks, compliance requirements (SOX, HIPAA, GxP), and zero-trust principles

Experience with monitoring and observability tools (Azure Monitor, Application Insights, Log Analytics, Grafana)

Experience with SaaS based virtual desktop solutions and corresponding profile management solutions (Azure Virtual Desktop, Windows 365, FSLogix)
Strong problem-solving abilities and capacity to troubleshoot complex technical issues Excellent communication skills with ability to translate technical concepts for non-technical stakeholders The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards.

Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much  this Hybrid-Eligible role, you can choose to be designated as:
1.

** Hybrid**: work remotely up to two days per week;
** or select
** 2.

** On-Site**: work five days per week on-site with ad hoc flexibility.
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