Senior Director, Business

Olema Oncology is dedicated to developing better medicines for breast cancer and beyond. Our lead program, palazestrant (OP-1250), is a complete estrogen receptor antagonist currently in development for metastatic breast cancer with blockbuster potential as a monotherapy and in combination in ER /HER2- metastatic breast cancer. Our follow‑on product candidate, OP-3136, is a potent KAT6 inhibitor with best‑in‑class potential. At Olema, we support, motivate, and challenge one another, putting people first to become second to none.

If you’re ready to join us at the edge of something unstoppable, let’s make a profound impact together for  our patients, your career, and what’s beyond .

Senior Director, Business Applications reports to the Vice President, Information Technology. You will oversee and optimize all General & Administrative (G&A) business systems, leading a high‑impact team to enhance, harden, and scale enterprise systems to support Olema’s transition toward commercialization and sustained growth. Based in either San Francisco or Boston with 10% travel.

• Own the strategic roadmap, budget, and day‑to‑day management of G&A business systems including Net Suite, Prendio, Agiloft, Bamboo
  
  HR, Greenhouse, and Culture Amp.
• Harden existing systems to prepare for commercialization and ensure enterprise scalability, audit readiness, and compliance with SOX (404A &
  
  B) requirements.
• Partner with Finance, HR, Legal, Procurement, Talent, Facilities, and IT teams to understand evolving business requirements and deliver efficient, scalable solutions.
• Ensure successful adoption of new technologies and enhancements through structured change management practices, including communication, training, and stakeholder alignment.
• Evaluate and implement AI‑driven tools and automation platforms—such as Workato or similar iPaaS technologies—to improve business performance and operational efficiency.
• Drive continuous improvement and digital transformation efforts by identifying opportunities for process redesign, automation, and integration across systems.
• Ensure application governance, data integrity, system security, and adherence to internal controls and SOX processes.
• Lead system and vendor evaluations, platform assessments, and RFP processes to achieve the optimal technical fit and value for the organization.
• Manage vendor relationships and contract negotiations for SaaS platforms and service providers.
• Provide oversight and partnership with R&D teams (~10% of your time) to support scientific applications, data workflows, and system integrations that enable research innovation.
• Mentor and grow a high‑performing Business Applications team aligned with Olema’s culture and mission.

• Bachelor’s degree in information systems, computer science, or related discipline; advanced degree preferred.
• Strong knowledge of AI technologies, data management, and automation tools to drive digital transformation.
• Demonstrated leadership in managing cross‑functional teams and complex system implementations.
• Proven success scaling and hardening systems in preparation for commercialization.
• Ability to translate business requirements into technical solutions and architect scalable, future‑ready systems.

• 10+ years of experience managing enterprise applications, with a strong background in G&A systems within the biotech or pharmaceutical industry.
• 5+ years of experience building, leading, managing, developing, and mentoring direct reports.
• Hands‑on experience with Net Suite is a must;
  Prendio, Agiloft, Bamboo
  
  HR, Greenhouse, Culture Amp, Workato or similar tools highly preferred.
• Track record of process optimization, workflow automation, and driving operational efficiency.
• Experience working within or preparing organizations for SOX compliance, including system controls, audit requirements, and governance.
• Proven success in system and vendor selection, including leading evaluations, RFPs, and contract negotiations.

• Exceptional communication skills and ability to influence stakeholders at all levels of the organization.
• Strong commitment to excellence and delivering outstanding…