Senior Manager – Partner, Global Health Economics

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OBJECTIVES/PURPOSE

• Contribute to the development and execution of health economics (HE) strategies and plans for Takeda oncology medicines. Drive hands‑on economic assessments for Takeda oncology medicines at all stages of development, using HE models and materials including systematic literature reviews (SLRs), indirect treatment comparisons (ITCs), statistical analyses of trial and real‑world data and other methods as appropriate
• Collaborate with cross‑functional counterparts to inform clinical development plans, evidence generation activities support, global market access plans, and pricing decisions
• Lead development of Global HE materials and provide support for country adaptations to regional and local operating company (LOC) patient value & access (PVA) and HE leads. Oversee country roll‑out and training on global HE materials and support country response to payer inquiries
• Propose and co‑lead robust publication plans for portfolio medicines through life cycle management, as well as above‑brand initiatives and activities aligned with Global Oncology HE and Global Oncology Pricing, Value & Access (PVA) priorities

ACCOUNTABILITIES

HE and Value & Access Tools

• Develop early HE models and comparative efficacy/effectiveness analyses to contribute to target product profiles and clinical development plans by understanding and communicating relevant HE and related outcome measures needed to achieve market access, including testing efficacy and pricing hypotheses, prioritizing payer‑relevant evidence generation, and planning for health technology appraisals (HTA; including the EU Joint Clinical Assessment [JCA]) across markets
• Lead the development of state‑of‑the‑art HE models and studies (e.g., SLRs, ITCs) with sufficient evidentiary support to withstand critique of HTA bodies and other key access decision makers
• Lead training to Regions and LOCs on product value, new evidence and HE studies and models

Payer‑related Evidence Generation

• Contribute to evidence generation planning to optimally demonstrate the product clinical, economic and humanistic value to payers, HTA bodies, and market access decision makers, and ensure payer and HE evidence needs are incorporated into Global, Regional and Local activities
• Evaluate the anticipated outcome of key HTAs (including JCA) and the implications for value positioning and evidence requirements, and shape the product’s ongoing evidence generation plan in partnership with Global PVA, Global Evidence and Outcomes (GEO) and Global Medical Affairs Oncology (GMAO)
• Make recommendations to cross‑functional business partners about the need for additional data generation – clinical trial, real world evidence (RWE) such as registries and databases – based on evidentiary requirements of payers and HTA bodies
• Ensure the integration of payer‑relevant HE endpoints and evidence needs in the clinical development plans

Global Value Proposition and Market Access

• Establish a comprehensive understanding of the burden of disease(s), unmet need and appropriate comparator
• Support Global PVA colleagues the development of the global value proposition to ensure a compelling value story for payers
• Support the development, review, and updating of the product value platform, including but not limited to Value Story, Global Value Dossiers, Objection Handler, Global Pricing Guidance
• Maintain awareness of the quickly evolving Global HTA (including JCA) and reimbursement landscape and the evidentiary needs of health care decision‑makers to guide HE and market access strategies

Communication/Publication and Foster Superior Collaboration

• Communicate and translate HE messages effectively in manuscripts, posters and publications, and support the development of appropriate communication tools for clinicians and payers as needed
• Foster productive…