Research Technician - Pikman Lab

A RESEARCH TECHNICIAN position is available in the laboratory of Dr. Yana Pikman ((Use the "Apply for this Job" box below).) at the Dana‑Farber Cancer Institute. Our research focuses on the application of clinical genomics for development of targeted therapy approaches for acute leukemia, drug testing and combination screening with the ultimate goals of
1) improving understanding of leukemia biology and
2) translating bench discovery to clinical care. You will join a team of investigators leading these efforts in the academic environment, working at the bench, collaborating closely with scientists as well as clinical researchers. You will play an essential, and possibly leading, role in project‑focused work.

Located in Boston and the surrounding communities, Dana‑Farber Cancer Institute is a leader in life‑changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high‑risk and underserved populations.

We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School‑affiliated hospitals.

• Conduct bench level experiments to support the goals of scientific research in leukemia and genomics
• Maintain cell lines and isolate primary cells for use in cell‑based assays
• Perform a variety of basic cancer biology assays including in‑vitro proliferation or apoptosis assays, drug sensitivity assays, flow cytometry and western blotting, in‑vivo xenograft experiments
• Perform a variety of molecular biology assays – cloning, PCR, DNA/RNA isolation
• Lentiviral transduction techniques for ORF‑over-expression experiments or CRISPR‑Cas9 knockdown/knockout experiments
• Operate and maintain laboratory equipment to complete investigations
• Prepare, order, and maintain stocks of necessary reagents, solutions and supplies
• Document, compile, and analyze experimental data; troubleshoot and solve scientific problems under supervision
• Report data in oral and written formats
• Monitor laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operating procedures specific to each laboratory
• Expected to provide intellectual and interactive commitment to the position by keeping up with appropriate literature and research publications
• May be responsible for designing and executing advanced experiments and setting strategy
• Participate in team meetings for experimental planning, discussion of projects and general learning
• Participate in research meetings at the DFCI and Boston Children’s Hospital

• Bachelor's degree in Biology or related field required, or equivalent combination of education and experience
• 1-2 years prior laboratory experience is strongly desired but not absolutely required; more experienced applicants who have worked for multiple years as a professional scientist or research technician are also encouraged to apply and would be considered at an appropriate level of compensation and benefits
• A history of hard work and sound academic achievement is required
• Familiarity with basic laboratory techniques and principles of molecular biology
• Experience working in a medical or scientific research setting or comparable technology‑oriented business environment
• Knowledge of computers and experience with databases
• Ability to analyze information and use logical reasoning to address work‑related issues and problems
• Ability to work within a team environment
• Must have attention to detail and be thorough in completing work tasks
• Excellent written and oral communication skills
• Strong organizational skills, including the ability to handle a variety of tasks in a fast‑paced environment required
• We are looking for candidates with a minimum of two years of availability; candidates with laboratory technician experience and those potentially interested in a long‑term position are…