Postdoctoral Fellow

College or Department: Roche Research Group

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The Roche Research Group at Florida Atlantic University is seeking a highly motivated Postdoctoral Fellow to join an interdisciplinary research program focused on developing next-generation peptide therapeutics targeting protein–protein interactions (PPIs) in inflammatory disease. This Leo Foundation–supported project leverages the ADAPT platform, a novel technology that converts antibody CDR‑H3 loops into β‑hairpin peptide mimetics with antibody‑like specificity and improved pharmacokinetic properties.

The primary biological focus is the inhibition of IL‑17 and IL‑23 signaling pathways relevant to psoriasis (I&I).

• Design, synthesize, and characterize CDR‑H3–mimetic β‑hairpin peptides using solid‑phase peptide synthesis (SPPS)
• Develop and screen non‑covalent and covalent peptide libraries
• Perform peptide folding and stability analyses (CD spectroscopy, VT‑CD)
• Conduct structural studies by NMR spectroscopy
• Collaborate on biochemical, cellular, and in vivo validation studies (ELISA, keratinocyte assays, murine psoriasis models)
• Analyze and integrate chemical, biophysical, and biological data for publication
• Contribute to manuscripts, grant reports, and collaborative discussions

• Ph.D. in Chemistry, Medicinal Chemistry, Chemical Biology, or a closely related field
• Strong background in synthetic organic or peptide chemistry
• Experience with SPPS and peptide purification (HPLC, LC‑MS)
• Ability to work independently while contributing to a collaborative research team

• Experience with peptide secondary structure analysis (CD, NMR)
• Familiarity with covalent inhibitors or protein–protein interaction modulators
• Interest in translational research and drug discovery

$62,000.00

Boca Raton

This position is open until filled and may close without prior notice. This position is subject to funding. All applicants must apply electronically to the currently posted position on the Office of Human Resources' job website () by completing the required employment application for this recruitment and submitting the related documents.

• CV
• Brief statement of research interests
• Contact information for 2–3 references

Transcripts:
Final candidate will be required to have official, sealed transcripts and original NACES evaluation, if applicable, sent from their educational institution to Human Resources prior to the start of employment.

Background Screening:
Selected candidates must successfully complete and pass all employment screenings prior to the start of employment. Employment screenings may include a criminal background check (level I and level II), motor vehicle check, credit check, reference checks, alcohol, and drug screening check.

Accommodations:
Individuals requiring accommodation, please call 561‑297‑3057.