Postdoctoral - Pediatric Brain Tumors; Tailor Lab

A full-time Post-Doctoral Research position is available in the Department of Neurological Surgery. The candidate will assist the principal investigator in conducting research on pediatric brain tumors, primarily pineoblastoma. Our research is focused on examining the molecular mechanisms of tumor progression and the identification of novel drug targets using genomic and proteomic techniques as well as human stem cell models. The candidate must be comfortable with advanced molecular biology techniques and bioinformatics.

We are seeking a self-directed, self-motivated, curious, creative, and well-organized candidate with experience in stem cell and cancer biology, molecular biology, next-generation sequencing techniques, bioinformatics, proteomic analysis, and animal handling to join our team.

IUSM is committed to being a welcoming campus community and we seek candidates whose research, teaching, and community engagement efforts contribute to robust learning and working environments for all students, staff, and faculty. We invite individuals who will join us in our mission to improve health equity and well-being for all throughout the state of Indiana.

Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure.

The growing residential base is supported by rich amenities and quality of life – the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named “Best Airport in North America” by Airports Council International for many years.

For additional information on life in Indy: (Use the "Apply for this Job" box below)..

• Bioinformatic analysis of single cell and next-generation RNA sequencing, and proteomic analysis of kinome data.
• Advanced molecular biology techniques including gene editing (CRISPR), plasmid design and production, bacterial culture, plasmid purification, and related analyses.
• Molecular biology and biochemical analyses including Western blotting, protein assays, PCR, RT-PCR, DNA and RNA purification and sequencing.
• Animal (mouse) handling/manipulations:
  Perform surgeries/implantations (will train), biopsies, bioluminescence imaging, and drug administration.
• Extensive tissue culture required.
• Flow cytometry and microscopy; phenotypic analysis and imaging.
• Keep organized analytical data of performed experiments and expected to report findings at lab meetings.
• Acts as a liaison/mentor to technicians, students and other laboratory personnel for training.
• Responsible for the initiation, monitoring, completion, and reporting of complex and intricate laboratory experiments. Organize and implement data review and analysis.
• Collaborate with other University Faculty and labs for common goals.
• Expected to keep current on relevant literature to identify suitable direction, new techniques, procedures and methods.
• Expected to submit research to national, professional meetings for possible presentations.
• Expected to publish in peer reviewed journals.