Principal Scientist, Bioinformatics

Overview

Principal Scientist, Bioinformatics – Quanterix is a global leader in ultra-sensitive biomarker detection, enabling breakthroughs in disease research, diagnostics, and drug development. Its proprietary Simoa technology delivers industry-leading sensitivity, allowing researchers to detect and quantify biomarkers in blood and other fluids at concentrations far below traditional limits. With more than 6,000 peer-reviewed publications, Quanterix has been a trusted partner to the scientific community for nearly two decades.

In 2025, Quanterix acquired Akoya Biosciences, The Spatial Biology Company, adding multiplexed tissue imaging with single-cell resolution to its portfolio. Together, the combined company offers a uniquely integrated platform that connects biology across blood and tissue - advancing precision medicine from discovery to diagnostics.

We are looking for an experienced and highly motivated Principal Scientist, Bioinformatics to join our Research and Technologies team in Billerica, MA. This is a high impact role with responsibility for leading innovative research and technology development in the area of Bioinformatics, biomarker and data analysis. The candidate will use their extensive knowledge to identify new potential biomarkers, conceive and prototype novel technologies and approaches leading to transformative products in the area of immunoassay and spatial biology.

• Work with key Company stakeholders to identify opportunities for new biomarker assays to build transformative products in the area of spatial biology and Simoa immunoassays
• Mine proteomic and genomic databases, scientific and patent literature and biological pathways to identify new biomarker candidates
• Design and execute analyses on large-scale omics data (genomics, proteomics)
• Utilize machine learning, AI, and statistical modeling to analyze complex spatial biology data sets
• Identify gaps in the existing product portfolio and opportunities for improvements
• Work with Research and Technologies team to support prototyping and feasibility
• Work with and support development team to transfer successful product candidates into development phase
• Support troubleshooting and advanced analytics for existing product portfolio

• PhD in Bioinformatics, Computational Biology, Computer Science, or related field
• Life Science tools industry experience
• 10+ years of technical experience
• Experience prototyping innovative concepts and development of commercial products
• Strong understanding of systems biology, drug discovery, and various omics technologies

• Experience in prototyping and developing spatial biology products
• Experience in spatial proteomics and spatial transcriptomics, multiomics including data analysis
• Knowledge of key technologies and players in the spatial biology area

• Work from Billerica, MA, on-site
• Ability to work in a fast-paced environment
• Work collaboratively with key stakeholders in key functional areas
• Entrepreneurial / start up mentality

Our Technology: From discovery to diagnostics, Quanterix's ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. Simoa technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins with industry leading Lower Level of Quantification (LLoQ). Our industry-leading precision instruments, digital immunoassay technology and CLIA-certified Accelerator laboratory have supported research that advances disease understanding and management in neurology, oncology, immunology, cardiology, and infectious disease.

Akoya Biosciences, a Quanterix company, is The Spatial Biology Company bringing tissue context to life through high-resolution, single-cell imaging. Akoya's spatial phenotyping platforms help researchers visualize and measure how cells organize and interact within tissue to influence disease progression and therapeutic response. From discovery through clinical research, Akoya offers a full continuum of solutions, including Pheno Cycler, Pheno Imager Fusion and HT, and Pheno Code Panels.

As part of Quanterix, Akoya complements a leading portfolio of ultra-sensitive biomarker detection technologies, together enabling a more complete view of biology and disease across both tissue and blood.

At Quanterix, our values are based on:
Team
, Innovation, Customer and Owner
.

Team
:
Challenge assumptions, not the person. Respect diversity of thought and hold ourselves to lofty standards

Innovation
:
Stay curious, experiment, create and change

Customer
:
Prioritize and celebrate these pioneers by doing our best to deliver on commitments

Owner
:
Act with high integrity and in the best interest of Quanterix. Take measured risks and learn from their success and failures.

We reward and recognize our employees by…