Postdoctoral visiting fellow

Overview

A fully-funded postdoctoral position is available immediately in the Tumor Evolution and Genomics Section of the Pediatric Oncology Branch (POB) to study the mechanisms of tumor evolution and relapse in pediatric cancers.

Despite an increasing knowledge of the molecular and genetic causes of pediatric tumors, patients with metastatic or relapsed tumors continue to have significant mortality. In addition, these patients are subjected to aggressive treatment regimens including surgery, radiation, and chemotherapy, which results in significant long-term morbidity. In order to address these significant therapeutic shortcomings, our laboratory uses cutting-edge technologies including single-cell sequencing, spatial profiling (RNA and protein), and CRISPR-mediated genome engineering to answer some of the most challenging and clinically relevant questions related to the tumor resistance and relapsed pediatric cancer.

The majority of the projects in the laboratory are highly translational, utilizing patient samples and model systems established from children treated at the NIH Clinical Center or on national consortium clinical trials. For more information, please visit Dr. Shern s website.

Successful candidates will undertake several exciting new projects in the general areas of Chromatin Biology, Epigenetics, and Transcription. They will employ a combination of molecular biology, biochemistry, and functional genomics to elucidate mechanisms of tumor resistance and discover new therapies for relapsed patients.

This is a full-time on-site role for a Postdoctoral Visiting Fellow, based in Bethesda, MD. The fellow will contribute to cutting-edge cancer research through laboratory experiments, data analysis, and collaboration with a team of scientists. Responsibilities include designing and conducting experiments, analyzing and interpreting data, and contributing to publications and presentations. The role also involves opportunities for teaching and mentoring junior researchers in the field.

• Proficiency in Laboratory Skills, including the design and execution of experiments
• Strong Research abilities, with expertise in fields such as biology, biochemistry, or related areas
• Solid understanding of Physics as it applies to biomedical research
• Experience in Data Analysis, with proficiency in relevant tools and methodologies
• Effective Teaching capabilities, with a passion for mentoring and knowledge sharing
• Excellent problem-solving skills, written and verbal communication abilities
• A Ph.D. or equivalent degree in a relevant scientific discipline

Applicants are invited to submit a CV, cover letter, and three references via email to john.shern or jou
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