Postdoctoral Fellow in Chromatin Biology and Genomics

Job Title: Postdoctoral Fellow in Chromatin Biology and Genomics

Job Number: 109453

Location: Bethesda, Maryland, US

A postdoctoral fellow position is available in the laboratory of Dr. Chongyi Chen at the National Cancer Institute (NCI), National Institutes of Health (NIH). The Chen lab has developed innovative genomic approaches to profile genomic DNA supercoiling and has identified topoisomerase-modulated large-scale supercoiling domains across the human genome, opening the door to multiple new research directions. The lab has also pioneered the development of single-cell transcriptome and nascent transcriptome profiling methods to study gene expression.

• Investigating the role of DNA supercoiling and DNA topoisomerase in gene regulation and/or genome instability during key biological processes and in disease contexts.
• Investigating the interplay between DNA supercoiling, DNA topoisomerase, and chromatin organization.

The Chen lab investigates the topological tension of DNA, known as DNA supercoiling, and its primary modulator, DNA topoisomerase, a key target in cancer chemotherapy. Leveraging our expertise in developing novel genomic technologies and single-cell assays, we explore how DNA supercoiling and topoisomerases interact with chromatin organization, regulating gene expression and contributing to genome instability in human cells. Our research aims to uncover the regulatory mechanisms and functional consequences of DNA supercoiling and topoisomerases in genome dynamics across various biological and biomedical processes.

The long‑term goal is to translate our discoveries in DNA topology and chromatin biology, along with our advanced genomic and single‑cell methodologies, into breakthroughs in cancer research and medicine. For more information about the lab and the PI, please visit: (Use the "Apply for this Job" box below).-chen

• The lab offers exciting opportunities to investigate disease‑related chromatin processes using state‑of‑the‑art genomic technologies, many of which are newly invented in‑house.
• The lab benefits from stable intramural funding, enabling a strong focus on high‑quality, long‑term research without the pressure and uncertainty of securing extramural grants.
• The lab is located on the NIH campus, which hosts over 1000 labs, 4000 postdoctoral fellows, and more than 100 members of the National Academy of Sciences/Medicine. NIH postdocs enjoy access to world‑class research resources, abundant opportunities to interact with leading scientists, and competitive salaries and benefits that often exceed those offered by academic institutions.

We seek highly motivated candidates with strong backgrounds in molecular and cell biology, genomics and bioinformatics, or related fields, who are passionate about pursuing innovative research. Interested applicants should send a CV, including the contact information of references, to [Please click the Apply button for the link or email]

Final date to receive applications: