PhD student position

Description

We are looking for a PhD candidate to study how the chemokine-like receptor ChemR
23 regulates arterial vascular inflammation. Particularly the project focuses on the therapeutic potential of selectively modulating ChemR
23 signaling within the arterial wall and surrounding perivascular adipose tissue. Within the project we will establish antibody-targeted lipid nanoparticle delivery of either anti-inflammatory (chemerin-9) or blocking ligands and will explore cell and context dependent RNAi of ChemR
23. Further, ligand milieu of ChemR
23, namely chemerin and resolvin E 1 will be modulated to determine whether enhancing ChemR
23-driven anti-inflammatory pathways can attenuate vascular inflammation and disease progression.

Applicants must comply with EU Doctoral Network mobility rules: doctoral candidates may not have resided or carried out their main activity in the recruiting country for more than 12 months in the 3 years preceding recruitment. Candidates of any nationality are eligible.

Eligible candidates should have experience with mouse models, immunological and molecular biological and 'omics' techniques, and a strong motivation and team spirit. German language skills would be helpful, solid English skills, written and spoken, are mandatory. The successful candidate should hold an above average Master degree or equivalent in biological sciences or related fields and should have a background in inflammatory immunology.

The PhD position is part of The Lipid

BRIGHT Consortium. As an European Doctoral Network Lipid

BRIGHT combines scientists, clinicians, companies and stakeholder organisations with expertise in these disease fields. By integrating expertise in lipids from the clinical, biomedical, technological and data science field across disease borders and by transferring complementary knowledge and technology, Lipid

BRIGHT aims to speed up innovations towards improved disease prevention, diagnosis, prognosis and therapy.

Lipid

BRIGHT will train scientists in a close cooperation between academia, SMEs and industry partners. Key objectives are to provide:
1) Excellent scientific training on interdisciplinary level, covering lipid biochemistry and pathophysiology as well as clinical application;
2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research; and
3) Exposure to both academic and non‑academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative products and services.

Lipid

BRIGHT builds on available patient cohorts, advanced technologies and established cooperations and strives to synergistically improve structural training on European level. Lipid

BRIGHT will nurture the development of young, broadly‑trained scientists able to successfully bridge clinical with basic research as well as academia and industry, which is a cornerstone in effectively combatting complex diseases such as cardiovascular disease, chronic kidney disease, cancer and chronic inflammatory disease.

Contributing partners in Lipid

BRIGHT:
Universiteit Maastricht (NL), Catholic University Leuven (BE), University Hasselt (BE), University Hospital Jena (DE), INSERM (FR), University Utrecht (NL), Sci Cross (SE), RD –Néphrologie SAS (FR), University of Bern (CH).

For more information: https://(Use the "Apply for this Job" box below)./