Scientist, Assay Development

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

We are seeking an experienced, hands‑on Assay Development Scientist to design and perform experiments that enable the next generation of sensitive, accurate, and scalable single‑molecule protein sequencing. Reporting to the Director of Assay Development, you will leverage your molecular biology expertise in a cross‑functional environment at the interface of molecular biology, chemistry, bioinformatics, and automation. The ideal candidate thrives at the bench in a dynamic research team and contributes to intellectually stimulating and highly collaborative projects.

This is a full‑time, exempt, in‑person position with work conducted at our Berkeley, CA location.

What you’ll do

• Plan, and execute experiments to improve the efficiency, accuracy, and scalability of Glyphic’s protein sequencing by expansion (ProSE) process
• Propose, design, and test novel analytical approaches to optimize and build predictive understanding of critical components of the ProSE sequencing process including sample preparation, molecular expansion chemistry, and automation integration
• Proactively identify, communicate, and help address experimental risks or resource gaps, such as reagent supply or instrument issues
• Collaborate with scientists on the Assay Development team to ensure successful delivery of team goals and prioritize experiments accordingly
• Collaborate with scientists in Chemistry, Bioinformatics, Process Development, and Engineering teams to assist and contribute to cross‑functional projects
• Collect, manage, and analyze data from molecular biology and protein sequencing experiments
• Keep a detailed electronic lab notebook on Confluence
• Communicate and present results in a timely manner

What you’ll need

Required
:

• BS/MS/PhD with 6+/4+/2+ (for Scientist II) or BS/MS/PhD with 4+/2+/0+ (for Scientist I) years of post‑graduate experience in molecular biology, biochemistry, chemistry or related fields
• Experience running and troubleshooting protocols for highly sensitive assays (PCR‑free sequencing, single cell assays, NULISA)
• Expertise and sound conceptual understanding of DNA‑based assays, including ligation, hybridization capture, qPCR, and gel electrophoresis
• Experience with and conceptual understanding of bead‑based DNA or protein purification and QC methods such as gel extraction, Tape station, Bioanalyzer, Seq Studio, and UV‑vis absorbance measurements
• Familiarity with chemical safety protocols for handling reagents such as strong acids and bases or working in anoxic and anhydrous environments (e.g., glove boxes)
• Academic exposure to organic chemistry
• Detail‑oriented, organized, and able to keep accurate lab records
• Strong written and verbal communication skills
• Ability to work independently and as a team member
• Motivated, enthusiastic, and proactive individual

Nice to have
:

• Experience with chemical functionalization of biomolecules or surfaces (e.g. EDC, NHS, Click)
• Experience with data analysis using Graph Pad Prism, Excel, and/or similar programs
• Experience with bead‑based automation on instruments such as King Fisher or Hamilton
• Familiarity with HPLC for biomolecule purification and validation is a plus
• Familiarity with emerging trends and techniques in proteomic measurements is a plus

We’re looking for teammates with
:

• Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels.
• High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
• Resourceful adaptability – operates with urgency, remains flexible in evolving environments, and thrives in ambiguity.
• Collaborative spirit –…