Senior​/Staff Scientist, Biopolymer Chemistry Berkeley, CA

Senior/Staff Scientist, Biopolymer Chemistry
About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$50M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

Glyphic is seeking a highly motivated and experienced Scientist to join the Chemistry Department to assist in the advancement of our cutting-edge single molecule proteome sequencing platform.

The ideal candidate will have a strong background in peptide chemistry, bioconjugation, analytical instrumentation, and be eager to contribute to transformative advances in proteomics. The scientist will work with a cross-disciplinary team of scientists, engineers, and bio-informaticians to rapidly deliver consistent results and insights that accelerate the development cycle.

What you’ll do

• Design, develop, and optimize high throughput chemical reagent evaluation for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility
• Synthesize assay specific reagents and materials for the proteome sequencing platform
• Develop and/or validate peptide sample preparation schemes, such as C-terminal conjugation and amino acid sidechain derivatization
• Collaborate with cross-functional teams to problem solve and integrate novel solutions into the assay workflow
• Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development
• Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control
• Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results
• Drive innovation in reagent and compound synthesis and design and contribute to intellectual property development

What you need

Required :

• Degree in chemistry, organic chemistry, or related field. Advanced degree preferred.
• 4+ years (PhD), 6+ years (MS), 8+ years (B.S.) of industry or equivalent experience in peptide chemistry
• Hands‑on development, optimization, and troubleshooting of solid‑phase peptide synthesis (SPPS) protocols.
• Experience developing methods for one or more of the following:
• advanced orthogonal protecting group strategies (beyond Fmoc/Boc);
• segment coupling methods akin to native chemical ligation and C‑terminal thioester intermediates; and/or
• selective on‑resin modification of aromatic sidechains (Trp, Tyr) for fluorophore labeling.
• Proven experience with bioconjugation and biorthogonal conjugation methods
• Analytical experience with HPLC, LC/MS, NMR, FTIR, UV/VIS, CE
• Experience in data analysis software
• Experience instatistical and DOE software

Nice to have :

• C‑terminal conjugation, and modification of amino acid sidechains beyond cysteine and lysine.
• Experience with nucleic acid synthesis, natural and modified analogs
• Knowledgeable about protein purification and fractionation from complex sample matrices
• Proficiency in scalable surface chemistry methods and techniques for flow cells and/or solid supports
• Experience in an industrial or startup setting
• Experience inthe development of commercial products

We’re looking for teammates with :

• Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels.
• High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
• Resourceful adaptability – operates with urgency, remains flexible in evolving environments, and thrives in ambiguity.
• Collaborative spirit – enjoys working across disciplines and explaining complex concepts to diverse audiences.

What you can expect

Work environment :

• Collaborative full-time in-person work at our Berkeley office
• Access to cutting‑edge technology in a top tier life science facility
• Collaborative culture where…