Senior Manager, Program Management
Listed on 2026-02-01
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IT/Tech
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Management
Program / Project Manager, Operations Manager
Position:
Senior Manager, Program Management
About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study.
Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico;
Biogen receives exclusive rest of world commercialization rights.
About Stoke: Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study.
Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico;
Biogen receives exclusive rest of world commercialization rights.
STK-002 is Stoke’s proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.
Stoke’s initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.
Position PurposeThe Senior Manager, Program Management is a flexible execution-enablement role within the Program Management function, designed to strengthen program management capability, infrastructure, and day-to-day execution support across internal teams.
The Senior Manager plays a critical role in driving program success by partnering closely with the lead Program Manager and the extended Program Team. Acting as a PM force multiplier, this role delivers hands-on project management support, strengthens PM ways of working, and builds scalable tools and processes by providing targeted expertise where it’s most needed to enable integrated planning and team cohesion.
This role offers significant growth through exposure to alliance program execution, cross-functional development work and PM capability building in a fast-moving biotech environment.
This position plays a pivotal role in enabling sub-teams and external partners to operate as high-performing execution engines, complementing the lead Program Managers’ integration and strategic Program Team leadership to ensure seamless delivery and alignment. This position will report into the Director, Program Management/Program Team Lead PM.
Key Responsibilities- Project Management Enablement & Sub-team Support:
Provide hands-on project management support to sub-team leads and sub-team managers to strengthen planning, tracking, and execution. - Support teams in applying core PM disciplines (e.g., work planning, milestone tracking, issue escalation, dependency awareness).
- Act as a trusted PM advisor to teams that do not have dedicated PM capacity, helping improve consistency and execution rigor.
- Execution Tracking & Risk…
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