Senior Scientist – Scale Oligonucleotide Synthesis

Location:

Basel, Switzerland

Full time, onsite, #LI-Onsite

At Novartis, we are reimagining medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible. How can we continue to advance our science to help even more patients in need?

We believe the answers are found when curious, courageous, and collaborative people are empowered to ask new questions, make bolder decisions, and take smarter risks.

At Biomedical Research in Basel, Switzerland, we are at the core of Novartis’ purpose, designing and making new molecules for treating patients. We are looking for a highly motivated, passionate researcher with a strong scientific background in chemistry or related life science disciplines, a curious mind‑set, and cultural agility to invent innovative medicines and advance the frontiers of drug discovery. Join us and help reimagine medicine!

The Biomedical Research RNAi Initiative is seeking a passionate, creative scientist to join our RNA synthesis team. You will work highly collaboratively in a multidisciplinary environment at the interface between research and development to discover and develop novel siRNA therapies for high unmet medical needs.

• Plan and execute small scale oligonucleotide syntheses by array‑based, automated synthetic technologies

• Experiment in a first‑class laboratory infrastructure and provide novel siRNAs to progress therapeutic siRNA projects

• Together with the project team, integrate experimental data to develop scientific hypotheses and prioritise novel oligonucleotide chemistries to address key project questions

• Support and coach other team members by sharing your know‑how and experience across your work environment

• Discuss and communicate scientific results at internal meetings and research boards

• Responsibility to maintain high levels of laboratory safety and infrastructure

• Masters educated with minimum 3 yrs + industry Pharma Lab experience with a focus on synthetic organic chemistry. PhD graduates within 6 months of their defence may be considered.

• Practical knowledge in small scale oligonucleotide synthesis is required

• Knowledge in conjugation to linkers, modifiers, payloads is considered a plus

• Passion for automated oligonucleotide chemistry experimentation in the laboratory

• Ability to critically interpret results, build new experimental hypotheses, and take calculated risks and smart decisions

• Interest in disruptive technologies and science trends, such as new drug modalities and automation, and their application to drug discovery and development

• A mindset of curiosity, creativity, collaboration and openness to diverse thinking, with an enthusiasm to develop yourself and others

• An organised working style, eye for detail, flexibility and commitment to high quality

• Aptitude to work in a fast‑paced team‑oriented matrix environment. To collaborate within a highly dynamic team, discuss science and contribute to siRNA discovery and development.

• Excellent oral and written communication skills

* Restrictions on flexible working requirements may apply and can be discussed at interview stages as necessary

Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclu and let us know the nature of your request and your contact information.

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