Head of Medicinal Chemistry & Early Research

Ridgeline Discovery
, a Versant Ventures Discovery Engine, creates and operates Versant-financed innovative biotech companies in partnership with entrepreneurs, industry, and leading academics across Europe. In recent years, Ridgeline has assembled an international team of >50 highly experienced drug discovery and industry professionals and built and operated multiple new successful companies; these companies have raised significant funds through Series B, IPO and an exit through a trade sale.

We are seeking an experienced and entrepreneurial d
rug discovery leader to strengthen and expand our RNA-focused small molecule discovery efforts and support the launch of new portfolio companies.

The ideal candidate has a strong track record of leading and executing small molecule medicinal chemistry program
s, with additional experience in RNA-targeted drug discovery considered a strong advantage.

The successful candidate will operate at the intersection of science and company-building, shaping pipeline strategy, building capabilities, and ensuring capital-efficient progression of programs from target identification through candidate nomination.

• Define and execute RNA-focused small molecule discovery strategies.
• Lead medicinal chemistry efforts across hit-to-lead and lead optimization.
• Develop robust SAR strategies and data-driven decision frameworks.
• Advance structured RNA-targeting approaches, including collaboration on assay and structural biology development.
• Build and mentor a high-performing early research team.
• Drive scientific strategy and execution across RNA-focused early discovery programs, partnering closely with biology and translational teams.
• Manage and oversee CRO and external research partnerships.
• Contribute to scientific discussions related to asset progression and platform differentiation.
• Represent the company at scientific conferences, board meetings, and investor presentations.

• PhD in Medicinal Chemistry, Organic Chemistry, or related discipline.
• 15+ years of pharmaceutical or biotech drug discovery experience.
• Proven track record of leading small molecule programs to candidate nomination.
• Experience in RNA-targeted small molecule discovery strongly preferred.
• Strong understanding of SAR strategy and synthetic chemistry.
• Familiarity with biophysical RNA-binding assays and structural biology.
• Strong understanding of intellectual property strategy and patent authorship.

• Entrepreneurial mindset and ability to operate in early-stage biotech environments.
• Strategic thinker with hands‑on execution capability.
• Strong cross‑functional collaborator and communicator.
• Decisive, data‑driven, and outcome‑oriented.

• People: We are an international, diverse, and highly collaborative team of talented, passionate, and science‑driven individuals.
• Creativity: We offer an innovative and creative environment where new ideas are encouraged and cutting‑edge science thrives.
• Development: We support the individual development of our employees.
• Impact & Entrepreneurship: Opportunity to help build and shape new biotech companies with direct impact on value creation.
• Innovation Platform: Opportunity to shape and expand a differentiated RNA‑targeted discovery platform.
• Strategic Involvement: Direct involvement in key scientific and strategic decisions.
• Fun: From time‑to‑time we organise cool off‑site summer and winter team events.
• Offices: Our well‑equipped laboratories and offices are located at the Tech Park, a premier address for early‑stage start‑ups in Basel.
• Commuter Benefits: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
• Flexible Working: We support flexible working as appropriate.
• Christmas Closure: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
• Birthday Retreat: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.

To apply
, please submit your completed application form along with your CV, cover letter, and reference letters
.

Head of Medicinal Chemistry Early Research
• Basel, Basel City, Switzerland