Lab Associate Cellular functional and soluble Biomarkers

Lab Associate for Cellular Functional and Soluble Biomarkers

This position is situated within the Bioanalytics and Biomarkers (BioAM) Chapter of the Pharmaceutical Sciences (PS). This funct chapter is accountable for developing Bioanalytical and Biomarker methods and implementing them in clinical studies to help guide drug development. Closely collaborate with different disease therapeutic areas and other functions to convert hypotheses into innovative therapeutics.

The ideal candidate is a proactive scientist with a Master's or Bachelor's degree and at least two years of industry experience in developing complex cellular and protein biomarker assays. They possess deep technical expertise in platforms like flow cytometry and ligand-binding assays (e.g., ELISA, MSD), coupled with a strong understanding of GxP regulations for clinical trial support. Beyond technical skill, this individual thrives in a matrixed environment, balancing hands-on lab work with the strategic management of external CRO partners to deliver high-quality, patient-focused data.

• Designing, developing, and transferring biomarker assays that support Roche clinical trials.
• Leading in‑house assay development; supporting method transfers to external CRO partners; ensuring the generation of robust, high‑quality biomarker data from method development through to clinical sample analysis.
• Self‑driven planning, development, troubleshooting and critical analysis of results of analytical methods for complex cellular, functional, and soluble protein biomarkers supporting preclinical and clinical drug development, in full compliance with regulatory and GxP requirements.
• Design and execute experimental protocols, generate, analyze, troubleshoot, interpret data, and deliver high‑quality reports aligned with project timelines.
• Support method transfer and implementation with external partners, ensuring proper documentation and efficient troubleshooting.
• Seek, evaluate and introduce novel technologies to enhance biomarker strategies and expand their application across therapeutic areas.
• Collaborate with internal/external stakeholders to ensure data integrity, technical and scientific rigor, and timely resolution of technical challenges.
• Present activities and results on internal/external meetings.
• Contribute to a culture of innovation, continuous improvement, and compliance with Safety, Security, Health, and Environmental (SHE) standards.

• Bachelor's or Master's degree (No PhD) in a relevant scientific discipline, with proven industry or CRO experience.
• Minimum of 2 years of experience in biomarker assay development within a regulated environment.
• Proficiency across diverse biomarker assay technologies, including:
  • Cellular and functional assays:
    Flow cytometry, pFlow, ELISpot/Fluoro Spot, HTRF.
  • Ligand-binding assays: ELISA, ELLA, Simoa, Elecsys, MSD.
• Hands‑on experience in technology implementation, optimization, and troubleshooting of bioanalytical/biomarker methods.
• Strong understanding of GxP principles.
• Experience supporting pharmacodynamic biomarker assay development for preclinical or clinical applications.
• Scientific credibility demonstrated through relevant publications and/or presentations at external conferences (1–2 is enough).
• You are a proactive team player who values collaboration, continuous learning, and scientific excellence.
• You exhibit a growth mindset and seek feedback to improve.
• Prioritize impact by simplifying and focusing on what matters most. You are customer‑and patient‑focused in your decision‑making.
• Embrace innovation and new technologies.
• Thrive in a fast‑paced, matrixed, agile environment. You value open communication and demonstrate a commitment to inclusion and teamwork.

We are fully committed to equal opportunity engagement and strive for diversity among our external workforce.