Post-Doctoral Fellow

Job Summary

A Postdoctoral Associate position is available immediately in the laboratory of Elan Eisenmesser at the University of Colorado School of Medicine (Anschutz Medical Campus).

Our group uses an integrative structural biology approach to understand how macromolecular structure and dynamics control function in systems relevant to infectious disease. We combine:

• Solution NMR spectroscopy (structure, dynamics)
• Cryo‑EM of large macromolecular assemblies
• Biochemistry and molecular biology

Current projects include:

• Bacterial proteases that manipulate host pathways, with emphasis on conformational exchange and its role in enzyme mechanisms.
• Macromolecular assemblies involved in microbial metabolism with a particular focus on protein‑protein regulatory mechanisms.

The successful candidate will apply advanced NMR methods and develop cryo‑EM expertise to study structure–dynamics–function relationships in these systems.

Onsite – this role is expected to work onsite and is located in Aurora, CO.

Our department conducts research across a wide biological scale for fundamental scientific understanding with applications to many disease contexts. The overarching goal is to reach a level of molecular insight that helps develop therapeutic approaches to disease.

As biochemists and molecular geneticists, we are amid an unprecedented time of discovery – our conception of the molecular biology of cells is going from grainy black‑and‑white to high‑resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes, and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell’s machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically.

The University of Colorado offers a comprehensive benefits package. To see what benefits are available for Post‑Doctoral Fellows, please visit:

• Payroll & Benefits Orientation for Post‑Doctoral Fellows | University of Colorado (cu.edu)
• Post‑Doctoral Benefits Guide

There are many additional perks & programs with the CU Advantage.

Applicants must meet minimum qualifications at the time of hire.

• A Ph.D. in biochemistry, structural biology, biophysics, or a related field
• Strong experience in biomolecular NMR

Experience with cryo‑EM is welcome but not required. The position is ideal for candidates interested in expanding from NMR into integrative structural biology. We seek a highly motivated scientist interested in linking macromolecular dynamics to biological function in a collaborative and fast‑paced environment.

• Strong written and verbal communication skills, including the ability to contribute to manuscripts and presentations
• Ability to lead and troubleshoot research projects
• Experience analyzing complex experimental or computational datasets and synthesizing results into clear conclusions
• Ability to mentor junior researchers and collaborate effectively within a multidisciplinary research environment
• Ability to manage multiple projects, meet research deadlines, and contribute positively to a rigorous and inclusive lab culture
• Expertise in protein expression and purification

• A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position
• Curriculum vitae / Resume
• Five professional references including name, address, phone number (mobile number if appropriate), and email address

Applications are accepted electronically ONLY .edu/cu-careers.

Questions should be directed to:
Elan Eisenmesser, Elan.

Eisenmesser

This position may be seeking multiple candidates. Positions will remain open until filled. Applications will be reviewed as they are received, and candidates may be contacted for interviews throughout the posting period. Upon candidate(s) selection, the posting will be closed, and no further applications will be accepted.

HIRING RANGE: $62,232 to $75,564

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