Scientist - Discovery Biology, Oncology

Position: Scientist - Discovery Biology, Oncology - No Experience Required
Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome.

We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.

We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Summary

We are seeking an experienced individual with cancer research and oncology drug discovery expertise to join the Discovery Biology team within the Oncology Thematic Research Center at Bristol-Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, interactive, creative scientist, with the ability to work across functions to advance small molecule programs from target discovery and validation to lead optimization, selection of drug candidate and IND-enabling biology related activities.

This individual will be dedicated to designing and executing experimental studies related to the decisional progress of our programs from early stages all the way through IND filling. The candidate will be involved in executing biology bench studies that will advance the understanding of mechanism of action as well as developing various cellular assays to enable compound triaging and identification of potential drug candidate.

In addition, the individual will work closely with other functions, such as informatics and predictive science, lead discovery and optimization, in vivo pharmacology, and translational research teams to design/execute work related to patient stratification, identification of appropriate PD markers and assay development/transfer for miniaturization, among others.

Position Responsibilities

In the role as a Scientist within Oncology Discovery Biology, the ideal candidate:

* Applies extensive scientific knowledge and technical skills to conduct molecular and cellular biology related studies to better understand target and disease biology

* Uses current and new technologies for function-based characterization for small molecule hit validation, mechanism of action understanding, and compound triaging/ranking

* Designs and executes molecular and cellular experiments independently, troubleshoots as needed, interprets and discusses data, with accurate, timely and detailed record-keeping

* Designing, optimizing, and executing molecular and cellular assays for cytotoxic payload screening, characterization, and mechanism of action studies

* Applying understanding of cancer biology to hypothesize and validate novel cytotoxic payloads and combination strategies

* Generating and characterizing relevant cancer cell models, including engineering drug-resistant lines and utilizing genetic tools (CRISPR, shRNA, siRNA, lentiviral over-expression).

* Conducting studies to evaluate small molecule or payload efficacy, selectivity, and synergy in 2D/3D/spheroid systems, and developing assays for cytotoxicity, proliferation, apoptosis, and high-content imaging.

* Collaborating closely with ADC biology, chemistry, pharmacology, and predictive…